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In COVID-19 Omicron patients, high blood pressure doubles risk of hospitalization

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People who have high blood pressure and Omicron-variant COVID-19 are at more than double the risk for hospitalization—even if they received three mRNA vaccine doses, according to a single-center study published yesterday in Hypertension.Cedars-Sinai Medical Center researchers studied 912 people in Los Angeles who tested positive for COVID after receiving at least three mRNA COVID-19 vaccine doses from Dec 1, 2021, to Apr 20, 2022.

A total of 145 (15.9%) were hospitalized, 125 (86.2%) of whom had high blood pressure (hypertension).Since Omicron was first identified in the United States in December 2021, seven subvariants have been detected; the study didn't differentiate among them.High blood pressure tied to 2.6 times risk of severe COVIDRisk factors for hospitalization included hypertension, older age, chronic kidney disease (CKD), heart attack (myocardial infarction [MI] or heart failure [HF]), and a longer interval between the last vaccine dose and infection.Hypertension, which carried a 2.6-fold increased risk, superseded all other risk factors in importance—even after excluding patients with CKD, MI, or HF and those taking an angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB).

Other previously identified risk factors for severe COVID-19, such as obesity and diabetes, weren't as strongly linked to hospitalization amid Omicron."Our results indicate persistence and even accentuation of hypertension-related risk in the setting of a more transmissible albeit generally less virulent strain," the researchers wrote. "Although the mechanism for hypertension-associated COVID-19 risk remains unclear, prior studies have identified delayed SARS-CoV-2 viral clearance and prolonged inflammatory

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